TGen Receives Approval for Patient Enrollment in Brain Cancer Clinical Trial

Glioblastoma (GBM) Pilot Trial funded by Ivy Foundation

In 2012, The Ben & Catherine Ivy Foundation awarded $10 million in grants for two groundbreaking brain cancer research projects at the Translational Genomics Research Institute (TGen). One of those projects has actually officially received the last regulatory approval from University of California, San Francisco, which means patient enrollment for the trial can easily begin.

In the $5-million-project, “Genomics Enabled Medicine in Glioblastoma Trial,” TGen and its clinical partners will certainly lead first-in-patient clinical trial studies that will certainly test promising brand-new drugs that could extend the survival of GBM patients. This multi-section study will certainly take place in clinics across the country and TGen laboratories.

“GBM is one of the top three fastest-killing cancers out there and it affects people of all of ages,” said Catherine (Bracken) Ivy, founder and president of The Ben & Catherine Ivy Foundation. “It is critical that we fund research that will certainly suggestions patients live longer so we can easily study and treat brain cancer.”

The project begins along with a pilot study of 15 patients, using whole genome sequencing to study their tumor samples to suggestions physicians figure out just what drugs may be most beneficial.

To support molecularly informed clinical decisions, TGen labs likewise will certainly examine genomic data from at least 536 past cases of glioblastoma, as well as tumor samples from brand-new cases, making tools that will certainly make a lot more help in to exactly how glioblastoma tumors grow and survive. TGen likewise will certainly conduct a collection of pioneering lab examinations to measure cell-by-cell responses to various drugs.

“GBM is a health problem that requires answers now, and we strongly believe those answers will certainly be found in the genome,” said Dr. David Craig, TGen’s Deputy Director of Bioinformatics, Director of TGen’s Neurogenomics Division, and one of the projects principal investigators. “Determining the genes that contribute to the survival of glioblastoma will certainly offer helpful short article on exactly how to treat it, and might likewise lead to an improved discovering of just what drives others cancers as well.”

To get hold of brand-new treatments to patients when possible, this five-year study will certainly include a feasibility study involving up to 30 patients, followed by Phase II clinical trials along with as lots of as 70 patients. TGen is teaming along with the Ivy Early Phase Clinical Trials Consortium that includes: University of California, San Francisco; University of California, Los Angeles; the MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; University of Utah; and the Dana-Farber/Harvard Cancer Center.

The results of these clinical trials must not only suggestions the patients that join them, however likewise offer the data required for FDA approval and availability of brand-new drugs that could benefit tens of thousands of brain cancer patients in the future.

“Working along with physicians, the project will certainly aim to understand treatment in the context of the tumor’s molecular profile. We will certainly have actually the opportunity to figure out as quickly as combinations of drugs may be a lot more effective compared to using a single drug, promptly identify which therapies don’t work, and accelerate discovery of ones that could prove promising for future development,” said Dr. John Carpten, TGen’s Deputy Director of Straightforward Science, Director of TGen’s Integrated Cancer Genomics Division, and an additional of the project’s principal investigators.

In addition to assisting patients when possible, the project must significantly expand Arizona’s network of brain cancer experts.

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About The Ben & Catherine Ivy Foundation
The Ben & Catherine Ivy Foundation, based in Scottsdale, Ariz., was formed in 2005, as quickly as Ben Ivy lost his battle along with glioblastoma multiforme (GBM). Because then, the Foundation has actually contributed a lot more compared to $50 million to research in gliomas within the United States and Canada, along with the objective of much better diagnostics and treatments that offer long-term survival and a higher quality of life for patients along with brain tumors. The Ben & Catherine Ivy Foundation is the largest privately funded foundation of its kind in the United States. For a lot more information, visit http://www.ivyfoundation.org. We have actually regular updates via social media – please locate us on:
Blog: Ivy Foundation http://www.IvyFoundation.wordpress.com
Facebook: Ivy Foundation http://www.facebook.com/IvyFoundation
Twitter: @IvyFoundation https://twitter.com/IvyFoundation
Google+: Ivy Foundation https://plus.google.com/115330378249248717618/posts
LinkedIn: Ivy Foundation http://linkedin.com/company/the-ben-and-catherine-ivy-foundation
YouTube: IvyFoundationGBM http://www.youtube.com/user/IvyFoundationGBM

About TGen
The Translational Genomics Research Institute (TGen) is a Phoenix-based non-profit organization dedicated to conducting groundbreaking research along with life changing results. Research at TGen is focused on assisting patients along with diseases such as cancer, neurological disorders and diabetes. TGen is on the cutting edge of translational research where investigators are able to unravel the genetic components of common and complex diseases. Working along with collaborators in the scientific and medical communities, TGen believes it can easily make a substantial supplement to the efficiency and effectiveness of the translational process. For a lot more information, visit: www.tgen.org.

Phoenix data center market back on track with leasing activity


The Phoenix metro location has actually the many energetic leasing market and the second largest multi-tenant data focus market in the country, according to a brand-new report.

CBRE’s Data focus Solutions Group’s quarterly, mid-year report likewise shows the regional market has actually 17 megawatts of expansion construction underway and two brand-new providers expected to enter the market next year.

Luke Denmon, a Phoenix market leader for the Data focus Solutions Group, said section of the growth is attributed to the brand-new statutory tax rewards and consistently reasonable energy costs in the area.

“Data focus supply and necessity resembles an inchworm. We had a great deal of inventory taken up by Digital Realty (Trust Inc.) and Cyrus One,” Denmon said. “Tenants looking for real-time, ready-to-go inventory makes the market truly attractive.”

A bill signed in to law in June 2013 gives the state a competitive edge along with tax exemptions for brand-new data focus building and infrastructure. The incentives, which began Sept. 1, are for the owner, operator and co-location tenants of data centers after meeting certain requirements.

Ascent, a St. Louis-based data focus firm along with a large presence in Chicago, has actually decided on Glendale for its westernmost expansion, Denmon said. Even though the firm has actually not yet announced construction strategies and is looking for an anchor tenant, strategies are to create on purchased land near 47th and Glendale avenues, he said.

The others data focus provider is a well-known, institutionally-known operator, however has actually not yet announced strategies publicly. The provider will certainly be opening in Phoenix, Denmon said.

“The thing to be aware of is from every severe metro market west of Mississippi, Phoenix has actually the lowest total occupancy rate,” Denmon said. “We have actually moderate electricity costs, lesser create costs due to the fact that we’re a non-union construction state and significantly lesser tax burdens.”

Hayley Ringle covers technology and startups for the Phoenix Company Journal.



Fountain Hills Market Statistics – December 2013


Fountain Hills Uncertaintyoffer Statistics – December 2013

Posted on January 14th, 201four by ScottsdaleHomes.com

Single Family Homes Sales Trends in Fountain Hills, December 2013

Single Household Residences Sales Fads in Fountain Hills, December 2013

December 2012 November 2013 December 2013 Monthly Modification in % Annual Modification in %
Asking Price $526,993 $481,392 $450,719 -6.37% -14.47%
Sale Price $507,558 $463,774 $434,562 -6.3% -14.38%
% of Asking Price 96.31% 96.34% 96.42% 0.08% 0.11%
Price/SqFt $173 $193 $180 -6.74% 4.05%
DOM* 109 109 100 -8.26% -8.26%
Total Transactions 43 25 42 68% -2.33%

Condos/Townhouses Sales Trends in Fountain Hills, December 2013

Condos/Townhouses Sales Fads in Fountain Hills, December 2013

December 2012 November 2013 December 2013 Monthly Modification in % Annual Modification in %
Asking Price $168,082 $185,089 $169,753 -8.29% 0.99%
Sale Price $156,364 $180,321 $162,413 -9.93% 3.87%
% of Asking Price 93.03% 97.42% 95.68% -1.79% 2.85%
Price/SqFt $122 $150 $132 -12% 8.2%
DOM* 51 101 108 6.93% 111.76%
Total Transactions 11 14 15 7.14% 36.36%

Single Household Residences Sales in Fountain Hills by Variety of Bedrooms and by Zip Code

Bedrooms Zip Code Average Asking Price Avergage Sale Price % of Asking Price Sold Average DOM Average SqFt Average Rate every SqFt
2 85268 $325,160 $312,000 95.95% 5 98 1,632 $191
3 85268 $446,373 $430,014 96.34% 22 117 2,271 $189
4 85268 $526,492 $507,615 96.41% 13 78 2,947 $172
5 85268 $389,900 $369,000 94.64% 1 99 2,237 $165
6 85268 $249,900 $263,300 105.36% 1 23 3,010 $87

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Scottsdale Fashion Square

We all of already know that there exists in the country certain neighborhoods and towns that have actually a reputation for being areas of higher class living. A perfect example would certainly be Scottsdale, Arizona. Scottsdale attracts the rich and famous from about the US and permanently reason. There exists a cosmopolitan charm too as beautiful climate, which make the location stand out head and shoulders above others towns. Scottsdale luxury homes embody a quality of the American dream that is not available in most others neighborhoods in the US. More importantly, Scottsdale luxury is a lifestyle all its own with an affluent luster unmatched in most places.

Over the past couple of decades, a lot of prestigious addresses have actually been built in the town. The neighborhoods now feature beautifully created avenues and streets, a lot of 18 hole golf courses, spas, sauna, galleries, restaurants, and top end shops. No matter exactly what your interests, you can easily be assured not to be left feeling bored if you move to Scottsdale.

The luxury properties that abound about Scottsdale are not simply earned to a higher quality, they additionally encompass a huge location of land. Several of the homes cover a space of 7,000 square feet or more, these estates are amongst the most desirable. There are additionally a lot more compact condominiums available that offer style and comfort at an affordable price.

Scottsdale has actually made its reputation as being a desirable town for a lot of various reasons. The climate is a huge draw, in the winter the temperature is not excessively cold, while throughout the summer months it stays pretty bearable. Humidity levels are constantly reduced as the region receives much less compared to seven inches of rain per year. Snow and frost are very rare in this section of the world. Along with a lot more compared to three hundred sunny days of the year, it is no surprise the residents appear so happy.

A problem that exists in several US urban centers today is pollution. The good news is this is not an issue that plagues Scottsdale. Even in the summer time, once a lot more tourists head to the town, congestion and crowding is not excessive.

The surrounding scenery is an additional draw. From most neighborhoods within Scottsdale you can easily view the mountains and desert that encircle the region. This corner of Arizona is perhaps the most beautiful.

several luxury homes in and about Scottsdale have actually large pools, patios, and spas. Relaxing and entertaining has actually never ever been so easy. There truly are selections that would certainly match the wants of any sort of family or retiree. Along with a lot of top end actual estate agents operating in the area, you can easily explain your requirements to them and sit spine to be given the most effective options.

As expected in a higher class community such as Scottsdale, the facilities in the location are second to none. You can easily locate state of the art medical clinics and hospitals, terrific schools, and professional businesses dotted about the town that offer the sort of services residents need. Along with a reduced crime rate, Scottsdale is unsurprisingly attractive.

If you have actually been looking for a property that offers twenty very first century quality and luxury, by relocating to Scottsdale you might locate the sort of lifestyle that you have actually constantly dreamt about. The only regret you might have, is that you didn’t come here earlier.

Scottsdale Stadium

The TPC of Scottsdale, Stadium Path is a fun, interesting layout set in the desert concerning 30 minutes north of the Phoenix Sky Harbor airport. The Path was originally constructed to be the brand-new residence of the FBR Open (nee Phoenix Open) a professional golf tournament that is a routine avoid on the PGA tour. The Path is section of a larger golf facility that likewise entails the Champions Course, yet another 18-hole layout that is situated across the street.

The clubhouse is very first rate, and entails lots of of the amenities that are frequently found only at private clubs, including an expansive locker room along with an attendant that is available to adjustment spikes or shine shoes. A huge pro-shop carries simply concerning any sort of kind of equipment or clothing that you could need. The Technique Facilities at the TPC of Scottsdale are globe class, and include multiple placing greens, a generous short game Technique area, and a huge driving range along with actual greens for targets (not simply flag sticks). It is not uncommon to see professional tour users out practicing on the range. Forecaddies can easily be hired on a round by round basis, and offer local knowledge of the Path including assisting your group to read greens and locate errant shots.

The Stadium Path was expertly created by Tom Weiskopf and Jay Morrish, and they did a wonderful task of incorporating a small number of water hazards in to the design of the Path to develop some truly memorable holes. There are several unique holes that are challenging and enjoyable to play free of the Path being overly frustrating.

The 8th Hole is a long Par 4 dogleg hole that plays to a maximum distance of 470 yards. A tough tee shot is essential to have actually any sort of possibility of reaching the green in regulation. Expect to hit a long iron or fairway wood to the green for your approach. Fortunately, the green is rather large and its only protection is gentle elevation modifications that ensconce the spine and sides of the green.

The 15th Hole is a true risk/reward par 5, playing to a maximum distance of 547 yards. The tee shot is protected by water that runs up the entire left adverse of the hole. A decent tee shot gives you the option of going for the green in two, yet the shot is all of carry. The green is defended by water on three sides, and drops off severely to the rear. The only safe place to skip the green is long, which means a difficult chip spine up the hill.

The 16th Hole is the famous stadium hole, which throughout the FBR Open is permanently enclosed by bleachers of rowdy fans. The bleachers can easily suit close to 40,000 people, and their behavior is not of the type frequently seen at professional golf tournaments. They applaud those that reach the green in regulation, and heckle those that do not. A wonderful shot produces cheers that rock the entire facility. It is all of done in wonderful fun, and is a actually unique experience in golf. As quickly as the tournament is not underway you can easily still see reminders of tournament weekend and the hole takes on a surreal quality to it. After hitting your tee shot, you can easily almost hear the thousands of supporters and their response to your effort.

The 17th Hole is a drivable par 4, playing to a distance of 332 yards. throughout the 2001 Phoenix Open, Andrew Magee carded the very first and only double eagle on a par 4 in PGA Tour history on this hole. A cautious drive is necessary, as water lurks to the two the right and left sides of the green, yet a good tee shot can easily put you in great placement to make a birdie. There is a small swatch of green in back, and if the pin is spine there ensure that to aim towards the focus of the green. Missing to the left or right As quickly as the pin is in spine is an automatic means to make sure a higher score.

Playing the TPC of Scottsdale can easily be a little pricey especially throughout peak season. The green fees max out at $272 per person from December through April. If you can easily bear the heat of playing golf in the middle of summer in the desert, the rates come down to as reasonable as $73 per person from June through August, and the Path is closed for the month of July. Included in the greens fees are a cart, range balls, a yardage schedule and bag tag, and a forecaddie for your group (throughout peak season only).

To reach the Stadium Path from Sky Harbor Airport, take Highway 51 concerning 15 miles north to the 101 Loop junction. Proceed east on the 101 Loop until you reach North Hayden Road. Turn right on North Hayden Road and proceed south for concerning a mile, the entrance to the Golf Path will certainly be on the right hand adverse of the street.